ONE-STEP PURIFICATION AND CHARACTERIZATION OF ALGINATE LYASE FROM A CLINICAL PSEUDOMONAS AERUGINOSA WITH DESTRUCTIVE ACTIVITY ON BACTERIAL BIOFILM

One-step purification and characterization of alginate lyase from a clinical Pseudomonas aeruginosa with destructive activity on bacterial biofilm

Objective(s): Pseudomonas aeruginosais a Gram-negative and aerobic rod bacterium that displays mucoid and non-mucoid phenotype.Mucoid strains secrete alginate, which is the main agent of biofilms in chronic P.aeruginosa infections, show high resistance to antibiotics; consequently, the biological disruption of mucoid P.aeruginosa biofilms is an att

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Luminal-contact-inhibition of epithelial basal stem cell multipotency in prostate organogenesis and homeostasis

Prostate epithelial basal cells are highly plastic in their luminal differentiation capability.Basal stem cells actively produce luminal cells during organogenesis, but become restricted in the adult prostate unless receiving oncogenic or inflammatory stimuli.Given that the number of luminal cells increases relative to basal cells through developme

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